Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells.

ABSTRACT: In a tumor cell, the development of acquired therapeutic resistance and the ability to survive in extracellular environments that differ from the primary site are the result of molecular adaptations in potentially highly plastic molecular networks. The accurate prediction of intracellular networks in a tumor remains a difficult problem in cancer informatics. In order to make truly rational patient-driven therapeutic decisions, it will be critical to develop methodologies that can accurately infer the molecular circuitry in the cells of a specific tumor. Despite enormous heterogeneity, cellular networks elicit deterministic digital-like responses. We discuss the use and limitations of methodologies that model molecular networks in cancer cells as a digital circuit. We also develop a network

SUBMITTER: Wynn ML 

PROVIDER: S-EPMC4218690 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature