Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model.

ABSTRACT: Helicobacter pylori infection of gastric tissue results in an immune response dominated by Th1 cytokines and has also been linked with dysregulation of Sonic Hedgehog (SHH) signaling pathway in gastric tissue. However, since interactions between the cytokines and SHH during H. pylori infection are not well understood, any mechanistic understanding achieved through interpretation of the statistical analysis of experimental results in the context of currently known circuit must be carefully scrutinized. Here, we use mathematical modeling aided by restraints of experimental data to evaluate the consistency between experimental results and temporal behavior of H. pylori activated cytokine circuit model. Statistical analysis of qPCR data from uninfected and H. pylori infected wild-type and pari

SUBMITTER: Marwaha S 

PROVIDER: S-EPMC4218723 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature