Functional analysis of atfA gene to stress response in pathogenic thermal dimorphic fungus Penicillium marneffei.

ABSTRACT: Penicillium marneffei, the pathogenic thermal dimorphic fungus is a causative agent of a fatal systemic disease, penicilliosis marneffei, in immunocompromised patients especially HIV patients. For growth and survival, this fungus has to adapt to environmental stresses outside and inside host cells and this adaptation requires stress signaling pathways and regulation of gene expression under various kinds of stresses. In this report, P. marneffei activating transcription factor (atfA) gene encoding bZip-type transcription factor was characterized. To determine functions of this gene, atfA isogenic mutant strain was constructed using the modified split marker recombination method. The phenotypes and susceptibility to varieties of stresses including osmotic, oxidative, heat, UV, cell wall and

SUBMITTER: Nimmanee P 

PROVIDER: S-EPMC4218842 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature