Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients.

ABSTRACT:

Objective

Dysregulation of the c-MET signaling pathway results from various molecular mechanisms including mutation, amplification, and overexpression. Overexpression and amplification of c-MET have been correlated with poor clinical outcome in gastric cancer, whereas the associations between c-MET polymorphisms and prognosis have not been well defined. We examined the prognostic impact of functional polymorphisms of the MET gene on clinical outcome in gastric cancer.

Methods

Candidate polymorphisms of the MET gene were analyzed by PCR-based direct sequencing for the associations with clinical outcome across three independent cohorts, including 161 Japanese, 101 US, and 63 Austrian patients, with locoregional gastric cancer, treated with surgery.

Results

The univariab

SUBMITTER: Sunakawa Y 

PROVIDER: S-EPMC4218879 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature