Clinical and economic consequences of hospital-acquired resistant and multidrug-resistant Pseudomonas aeruginosa infections: a systematic review and meta-analysis.

ABSTRACT:

Background

Increasing rates of resistant and multidrug-resistant (MDR) P. aeruginosa in hospitalized patients constitute a major public health threat. We present a systematic review of the clinical and economic impact of this resistant pathogen.

Methods

Studies indexed in MEDLINE and Cochrane databases between January 2000-February 2013, and reported all-cause mortality, length of stay, hospital costs, readmission, or recurrence in at least 20 hospitalized patients with laboratory confirmed resistant P. aeruginosa infection were included. We accepted individual study definitions of MDR, and assessed study methodological quality.

Results

The most common definition of MDR was resistance to more than one agent in three or more categories of antibiotics. Twenty-three stud

SUBMITTER: Nathwani D 

PROVIDER: S-EPMC4219028 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature