The influence of BsmI and TaqI vitamin D receptor gene polymorphisms on the intensity of hyperparathyroidism in Iranian hemodialysis patients.

ABSTRACT:

Background

The influence of vitamin D receptor (VDR) gene polymorphisms on the regulation of the parathyroid hormone is important in end-stage renal disease (ESRD) patients. We analyzed rs1544410 (BsmI) and rs731236 (TaqI) polymorphisms of VDR gene in hemodialysis patients to determine their relationship with serum intact parathyroid hormone (iPTH).

Materials and methods

Ninety hemodialysis patients were included in this study. Patients were classified into four groups according to their serum iPTH level. Polymorphisms of VDR gene were surveyed using polymerase chain reaction-restriction fragment length polymorphism method with BsmI and TaqI enzymes in all the patients.

Results

Patients age ranged between 30 and 60 years (mean ± SD: 36.0 ± 11.4) and period undergoing

SUBMITTER: Pourfarzam M 

PROVIDER: S-EPMC4219211 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature