Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study.

ABSTRACT:

Background

MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels relate to AF are limited.

Objective

The purpose of this study was to test the hypothesis that circulating miRNAs are associated with AF.

Methods

Among 2445 Framingham Heart Study Offspring participants, we measured the expression of 385 circulating whole blood miRNAs by high-throughput quantitative reverse transcriptase polymerase chain reaction. We related miRNA levels with prevalent and new-onset AF.

Results

Mean age of the cohort was 66.3 ± 8.9 years, and 56% were women; 153 participants had clinically apparent AF at baseline, and 107 developed AF during median follow-up of 5.4 year

SUBMITTER: McManus DD 

PROVIDER: S-EPMC4219255 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature