Evolution and dynamics of megaplasmids with genome sizes larger than 100 kb in the Bacillus cereus group.

ABSTRACT:

Background

Plasmids play a crucial role in the evolution of bacterial genomes by mediating horizontal gene transfer. However, the origin and evolution of most plasmids remains unclear, especially for megaplasmids. Strains of the Bacillus cereus group contain up to 13 plasmids with genome sizes ranging from 2 kb to 600 kb, and thus can be used to study plasmid dynamics and evolution.

Results

This work studied the origin and evolution of 31 B. cereus group megaplasmids (>100 kb) focusing on the most conserved regions on plasmids, minireplicons. Sixty-five putative minireplicons were identified and classified to six types on the basis of proteins that are essential for replication. Twenty-nine of the 31 megaplasmids contained two or more minireplicons. Phylogenetic analysis of

SUBMITTER: Zheng J 

PROVIDER: S-EPMC4219350 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature