Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates.

ABSTRACT:

Importance

Chorioamnionitis is strongly linked to preterm birth and neonatal infection. The association between histological and clinical chorioamnionitis and cognitive, behavioral, and neurodevelopmental outcomes among extremely preterm neonates is less clear. We evaluated the impact of chorioamnionitis on 18- to 22-month neurodevelopmental outcomes in a contemporary cohort of extremely preterm neonates.

Objective

To compare the neonatal and neurodevelopmental outcomes of 3 groups of extremely low-gestational-age infants with increasing exposure to perinatal inflammation: no chorioamnionitis, histological chorioamnionitis alone, or histological plus clinical chorioamnionitis.

Design, setting, and participants

Longitudinal observational study at 16 centers of the Euni

SUBMITTER: Pappas A 

PROVIDER: S-EPMC4219500 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature