Synthesis, characterization, and stability of iron (III) complex ions possessing phenanthroline-based ligands.

ABSTRACT: It has previously been demonstrated that phenanthroline-based ligands used to make gold metallotherapuetics have the ability to exhibit cytotoxicity when not coordinated to the metal center. In an effort to help assess the mechanism by which these ligands may cause tumor cell death, iron binding and removal experiments have been considered. The close linkage between cell proliferation and intracellular iron concentrations suggest that iron deprivation strategies may be a mechanism involved in inhibiting tumor cell growth. With the creation of iron (III) phen complexes, the iron binding abilities of three polypyridal ligands [1,10-phenanthroline (phen), 2,9-dimethyl-1, 10-phenanthroline (^methylphen), and 2,9-di-sec-butyl-1, 10-phenanthroline ( ^sec-butylph

SUBMITTER: Tosonian S 

PROVIDER: S-EPMC4219584 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature