Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau.

ABSTRACT: Identifying replicable genetic variants for addiction has been extremely challenging. Besides the common difficulties with genome-wide association studies (GWAS), environmental factors are known to be critical to addiction, and comorbidity is widely observed. Despite the importance of environmental factors and comorbidity for addiction study, few GWAS analyses adequately considered them due to the limitations of the existing statistical methods. Although parametric methods have been developed to adjust for covariates in association analysis, difficulties arise when the traits are multivariate because there is no ready-to-use model for them. Recent nonparametric development includes U-statistics to measure the phenotype-genotype association weighted by a similarity score of covariates. Howe

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC4219655 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature