Tempo and mode of gene duplication in mammalian ribosomal protein evolution.

ABSTRACT: Gene duplication has been widely recognized as a major driver of evolutionary change and organismal complexity through the generation of multi-gene families. Therefore, understanding the forces that govern the evolution of gene families through the retention or loss of duplicated genes is fundamentally important in our efforts to study genome evolution. Previous work from our lab has shown that ribosomal protein (RP) genes constitute one of the largest classes of conserved duplicated genes in mammals. This result was surprising due to the fact that ribosomal protein genes evolve slowly and transcript levels are very tightly regulated. In our present study, we identified and characterized all RP duplicates in eight mammalian genomes in order to investigate the tempo and mode of ribosomal pr

SUBMITTER: Dharia AP 

PROVIDER: S-EPMC4219774 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature