Use of 1H-nuclear magnetic resonance to screen a set of biomarkers for monitoring metabolic disturbances in severe burn patients.

ABSTRACT:

Introduction

To establish a plasma metabolomics fingerprint spectrum for severe burn patients and to use it to identify a set of biomarkers that could be used for clinical monitoring.

Methods

Twenty-one severe burn patients and three healthy control individuals were enrolled in this study, and the plasma samples from patients and healthy individuals were collected for nuclear magnetic resonance (NMR) measurements. The NMR spectra were analyzed using principal component analysis (PCA) and partial least squares (PLS) in order to establish the metabolomics fingerprint representing the changes in metabolism and to select the major biomarkers.

Results

NMR spectra of the plasma samples showed significant differences between burn patients and healthy individuals. Using metab

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4220088 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature