Electrostatics of the FeS clusters in respiratory complex I.

ABSTRACT: Respiratory complex I couples the transfer of electrons from NADH to ubiquinone and the translocation of protons across the mitochondrial membrane. A detailed understanding of the midpoint reduction potentials (E(m)) of each redox center and the factors which influence those potentials are critical in the elucidation of the mechanism of electron transfer in this enzyme. We present accurate electrostatic interaction energies for the iron-sulfur (FeS) clusters of complex I to facilitate the development of models and the interpretation of experiments in connection to electron transfer (ET) in this enzyme. To calculate redox titration curves for the FeS clusters it is necessary to include interactions between clusters, which in turn can be used to refine E(m) values and validate spectroscopic

SUBMITTER: Couch VA 

PROVIDER: S-EPMC4220734 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature