Gene-gene and gene-environment interactions in apolipoprotein L1 gene-associated nephropathy.

ABSTRACT: Molecular genetics have revolutionized the understanding of susceptibility to the broad spectrum of kidney diseases with light microscopic appearance of FSGS, particularly in populations with recent African ancestry. These disorders include idiopathic FSGS, HIV-associated nephropathy, severe lupus nephritis, sickle cell nephropathy, and the primary kidney disorder focal global glomerulosclerosis, which had historically been ascribed to systemic hypertension. FSGS was once thought to include a multitude of unrelated disorders with similar histologic appearance. However, variation in the apolipoprotein L1 gene locus is now known to account for the vast majority of such cases in African Americans as well as nearly all the excess risk for FSGS and related forms of progressive nondiabetic nephr

SUBMITTER: Freedman BI 

PROVIDER: S-EPMC4220749 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature