Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study.

ABSTRACT:

Objective

To determine the association between depth of excision of cervical intraepithelial neoplasia and risk of preterm birth.

Design

Case-control study nested in record linkage cohort study.

Setting

12 hospitals in England.

Participants

From a cohort of 11 471 women with at least one histological sample taken at colposcopy and a live singleton birth (before or after colposcopy), 1313 women with a preterm birth (20-36 weeks) were identified and frequency matched on maternal age at delivery, parity, and study site to 1313 women with term births (38-42 weeks).

Main outcome measures

Risk of preterm birth and very/extreme preterm birth by depth of excisional treatment of the cervical transformation zone.

Results

After exclusions, 768 preterm births

SUBMITTER: Castanon A 

PROVIDER: S-EPMC4220819 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature