Quantitative method for the assignment of hinge and shear mechanism in protein domain movements.

ABSTRACT:

Motivation

A popular method for classification of protein domain movements apportions them into two main types: those with a 'hinge' mechanism and those with a 'shear' mechanism. The intuitive assignment of domain movements to these classes has limited the number of domain movements that can be classified in this way. Furthermore, whether intended or not, the term 'shear' is often interpreted to mean a relative translation of the domains.

Results

Numbers of occurrences of four different types of residue contact changes between domains were optimally combined by logistic regression using the training set of domain movements intuitively classified as hinge and shear to produce a predictor for hinge and shear. This predictor was applied to give a 10-fold increase in the number

SUBMITTER: Taylor D 

PROVIDER: S-EPMC4221117 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature