Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study.

ABSTRACT:

Background

Multiple primary cancers account for approximately 16% of all incident cancers in the United States. Although genome-wide association studies (GWAS) have identified many common genetic variants associated with various cancer sites, no study has examined the association of these genetic variants with risk of multiple primary cancers (MPC).

Methods

As part of the National Human Genome Research Institute (NHGRI) Population Architecture using Genomics and Epidemiology (PAGE) study, we used data from the Multiethnic Cohort (MEC) and Women's Health Initiative (WHI). Incident MPC (IMPC) cases (n = 1,385) were defined as participants diagnosed with more than one incident cancer after cohort entry. Participants diagnosed with only one incident cancer after cohort entry wit

SUBMITTER: Park SL 

PROVIDER: S-EPMC4221293 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature