Prediagnostic circulating anti-Mullerian hormone concentrations are not associated with prostate cancer risk.

ABSTRACT: Despite considerable research, the pathogenesis of prostate cancer remains poorly understood. Meanwhile, PSA testing has shifted prostate cancer case populations for study to include a greater proportion of asymptomatic and indolent disease. Thus, efforts to identify prostate cancer biomarkers-particularly for aggressive disease-are required to elucidate pathogenesis and aid screening efficacy. Current evidence suggests that decreased circulating concentrations of the testis-derived, TGFβ family peptide hormone-anti-Müllerian hormone (AMH)-may be associated with prostate cancer pathogenesis. To test this hypothesis, we measured AMH concentrations in prediagnostic (cohort baseline) sera using the Beckman Coulter AMH Gen II ELISA in 1,000 cases and 1,000 controls nested within the Prostate,

SUBMITTER: Sklavos MM 

PROVIDER: S-EPMC4221416 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature