The role of genome sequencing in personalized breast cancer prevention.

ABSTRACT:

Background

There is uncertainty about the benefits of using genome-wide sequencing to implement personalized preventive strategies at the population level, with some projections suggesting little benefit. We used data for all currently known breast cancer susceptibility variants to assess the benefits and harms of targeting preventive efforts to a population subgroup at highest genomic risk of breast cancer.

Methods

We used the allele frequencies and effect sizes of 86 known breast cancer variants to estimate the population distribution of breast cancer risks and evaluate the strategy of targeting preventive efforts to those at highest risk. We compared the efficacy of this strategy with that of a "best-case" strategy based on a risk distribution estimated from breast cancer

SUBMITTER: Sieh W 

PROVIDER: S-EPMC4221442 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature