The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer.

ABSTRACT:

Background

Although colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain undefined. GUCY2C has emerged as an intestine-specific tumor suppressor controlling epithelial homeostasis through circuits canonically disrupted in cancer. Surprisingly, the GUCY2C tumor suppressor is universally overexpressed by human colorectal cancer cells. This apparent paradox likely reflects silencing of GUCY2C through loss of its paracrine hormone guanylin. Here, we quantified expression of guanylin mRNA and protein in tumors and normal epithelia from patients with colorectal cancer.

Methods

Guanylin mRNA was quantified in tumors and normal adjacent epithelia f

SUBMITTER: Wilson C 

PROVIDER: S-EPMC4221461 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature