The oral microbiota of patients with recurrent aphthous stomatitis.

ABSTRACT:

Background

Specific pathogenic bacteria have been implicated in recurrent aphthous stomatitis (RAS), a chronic inflammatory condition characterised by ulcerations in the oral mucosa. However, the aetiology behind this condition still remains unclear.

Objective

The buccal microbiota of patients with RAS was compared to that of control subjects to investigate its potential role for this condition.

Design

Buccal swabs were obtained from non-ulcerative areas of 60 patients, of whom 42 patients had lesions at the time of sampling, and 60 healthy age- and gender-matched controls. Bacterial DNA was extracted and analysed by Terminal-Restriction Fragment Length Polymorphism, using enzymatic digestion of the polymerase chain reaction-amplified 16S rRNA gene, yielding a series

SUBMITTER: Bankvall M 

PROVIDER: S-EPMC4221501 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature