Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer.

ABSTRACT:

Background

MicroRNAs (miRNA) play important roles in the regulation of eukaryotic gene expression and are involved in human carcinogenesis. Single-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in turn, may affect cancer risk and disease progression.

Methods

We conducted an analysis of associations of 142 miRNA SNPs with non-small cell lung cancer (NSCLC) survival using data from a genome-wide association study (GWAS) in a Caucasian population from the Massachusetts General Hospital (Boston, MA) including 452 early-stage and 526 late-stage NSCLC cases. Replication analyses were further performed in two external populations, one Caucasian cohort from The University of Texas MD Anderson Cancer Center (Houston, TX) and one

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC4221531 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature