Immunologic characterization suggests reduced alloimmunization in a murine model of thalassemia intermedia.

ABSTRACT:

Background

Transfusion therapy remains a mainstay of treatment for patients with thalassemia major and to a lesser extent for the less anemic patients with thalassemia intermedia. We have previously reported a role for regulatory T cells (Tregs) in the control of antibody responses in wild-type C57BL/6 (WT) mice exposed to allogeneic red blood cell transfusions. As an initial step to study and characterize immune regulation in thalassemias, we performed an immunologic cell-type characterization of C57BL/6 Hbb(th-1)/Hbb(th-1) mouse model of thalassemia intermedia (Thal) in steady state as well as after transfusions with allogeneic blood.

Study design and methods

The myeloid and lymphocyte compartments including Tregs and T helper (Th) responses were analyzed in transfusion na

SUBMITTER: Bao W 

PROVIDER: S-EPMC4221584 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature