Hybrid Nanomaterial Complexes for Advanced Phage-guided Gene Delivery.

ABSTRACT: Developing nanomaterials that are effective, safe, and selective for gene transfer applications is challenging. Bacteriophages (phage), viruses that infect bacteria only, have shown promise for targeted gene transfer applications. Unfortunately, limited progress has been achieved in improving their potential to overcome mammalian cellular barriers. We hypothesized that chemical modification of the bacteriophage capsid could be applied to improve targeted gene delivery by phage vectors into mammalian cells. Here, we introduce a novel hybrid system consisting of two classes of nanomaterial systems, cationic polymers and M13 bacteriophage virus particles genetically engineered to display a tumor-targeting ligand and carry a transgene cassette. We demonstrate that the phage complex with cation

SUBMITTER: Yata T 

PROVIDER: S-EPMC4221597 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature