Tranexamic acid for patients with traumatic brain injury: a randomized, double-blinded, placebo-controlled trial.

ABSTRACT:

Background

Traumatic brain injury (TBI) is commonly accompanied by intracranial bleeding which can worsen after hospital admission. Tranexamic acid (TXA) has been shown to reduce bleeding in elective surgery and there is evidence that short courses of TXA can reduce rebleeding in spontaneous intracranial haemorrhage. We aimed to determine the effectiveness and safety of TXA in preventing progressive intracranial haemorrhage in TBI.

Methods

This is a double blinded, placebo controlled randomized trial. We enrolled 238 patients older than 16 years with moderate to severe TBI (post-resuscitation Glasgow Coma Scale (GCS) 4 to 12) who had a computerized tomography (CT) brain scan within eight hours of injury and in whom there was no immediate indication for surgery. We excluded p

SUBMITTER: Yutthakasemsunt S 

PROVIDER: S-EPMC4221638 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature