Unveiling nonessential gene deletions that confer significant morphological phenotypes beyond natural yeast strains.

ABSTRACT:

Background

Phenotypes are variable within species, with high phenotypic variation in the fitness and cell morphology of natural yeast strains due to genetic variation. A gene deletion collection of yeast laboratory strains also contains phenotypic variations, demonstrating the involvement of each gene and its specific function. However, to date, no study has compared the phenotypic variations between natural strains and gene deletion mutants in yeast.

Results

The morphological variance was compared between 110 most distinct gene deletion strains and 36 typical natural yeast strains using a generalized linear model. The gene deletion strains had higher morphological variance than the natural strains. Thirty-six gene deletion mutants conferred significant morphological changes

SUBMITTER: Yang M 

PROVIDER: S-EPMC4221665 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature