Transcriptional and epigenetic responses to mating and aging in Drosophila melanogaster.

ABSTRACT:

Background

Phenotypic plasticity allows organisms to respond rapidly to changing environmental circumstances, and understanding its genomic basis can yield insights regarding the underlying genes and genetic networks affecting complex phenotypes. Female Drosophila melanogaster undergo dramatic physiological changes mediated by seminal fluid components transferred upon mating, including decreased longevity. Their physiological and behavioral effects have been well characterized, but little is known about resulting changes in regulation of gene expression or the extent to which mating-induced changes in gene expression are the same as those occurring during aging.

Results

We assessed genome-wide mRNA, microRNA, and three common histone modifications implicated in gene activati

SUBMITTER: Zhou S 

PROVIDER: S-EPMC4221674 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature