A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection.

ABSTRACT:

Background

The presence of an asymptomatic phase in an HIV infection indicates that the immune system can partially control the infection. Determining the immune mechanisms that contribute significantly to the partial control of the infection enhance the HIV infection intervention strategies and is important in vaccine development. Towards this goal, a discrete time HIV model, which incorporates the life cycle aspects of the virus, the antibody (humoral) response and the cell-mediated immune response is formulated to determine immune system components that are most efficient in controlling viral levels. Ecological relationships are used to model the interplay between the immune system components and the HIV pathogen. Model simulations and transient elasticity analysis of the viral

SUBMITTER: Showa SP 

PROVIDER: S-EPMC4221687 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature