Unexpected structure of Epstein-Barr virus lytic cycle activator Zta.

ABSTRACT: The key viral gene responsible for initiating the replicative cycle of Epstein-Barr virus (EBV), termed BZLF1, encodes the multifunctional protein Zta (ZEBRA or Z). It interacts with DNA as both a transcription and a replication factor, modulates both intracellular signal transduction and the DNA-damage response and manipulates cell cycle progression. Muller and colleagues have resolved the structure of Zta bound to DNA, which confirms some structural predictions but reveals an unexpected twist and a complex dimerization interface. Because EBV is associated with human disease, Zta presents a prime target for drug design.

SUBMITTER: Sinclair AJ 

PROVIDER: S-EPMC4221735 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature