Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach.

ABSTRACT: Although protein S (PROS1) and growth arrest-specific protein 6 (GAS6) proteins are homologous with a high degree of structural similarity, they are functionally different. The objectives of this study were to identify the evolutionary origins from which these functional differences arose. Bioinformatics methods were used to estimate the evolutionary divergence time and to detect the amino acid residues under functional divergence between GAS6 and PROS1. The properties of these residues were analysed in the light of their three-dimensional structures, such as their stability effects, the identification of electrostatic patches and the identification potential protein-protein interaction. The divergence between GAS6 and PROS1 probably occurred during the whole-genome duplications in vertebr

SUBMITTER: Studer RA 

PROVIDER: S-EPMC4221892 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature