Integrated molecular portrait of non-small cell lung cancers.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC), a leading cause of cancer deaths, represents a heterogeneous group of neoplasms, mostly comprising squamous cell carcinoma (SCC), adenocarcinoma (AC) and large-cell carcinoma (LCC). The objectives of this study were to utilize integrated genomic data including copy-number alteration, mRNA, microRNA expression and candidate-gene full sequencing data to characterize the molecular distinctions between AC and SCC.

Methods

Comparative genomic hybridization followed by mutational analysis, gene expression and miRNA microarray profiling were performed on 123 paired tumor and non-tumor tissue samples from patients with NSCLC.

Results

At DNA, mRNA and miRNA levels we could identify molecular markers that discriminated significantl

SUBMITTER: Lazar V 

PROVIDER: S-EPMC4222074 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature