Evolution of invasion in a diverse set of Fusobacterium species.

ABSTRACT:

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The diverse Fusobacterium genus contains species implicated in multiple clinical pathologies, including periodontal disease, preterm birth, and colorectal cancer. The lack of genetic tools for manipulating these organisms leaves us with little understanding of the genes responsible for adherence to and invasion of host cells. Actively invading Fusobacterium species can enter host cells independently, whereas passively invading species need additional factors, such as compromise of mucosal integrity or coinfection with other microbes. We applied whole-genome sequencing and comparative analysis to study the evolution of active and passive invasion strategies and to infer factors associated with active forms of host cell invasion. The evolution of active invasion appears to

SUBMITTER: Manson McGuire A 

PROVIDER: S-EPMC4222103 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature