Functional dissociation of adult-born neurons along the dorsoventral axis of the dentate gyrus.

ABSTRACT: Adult-born granule cells in the mammalian dentate gyrus have long been implicated in hippocampal dependent spatial learning and behavioral effects of chronic antidepressant treatment. Although recent anatomical and functional evidence indicates a dissociation of the dorsal and ventral regions of the hippocampus, it is not known if adult neurogenesis within each region specifically contributes to distinct functions or whether adult-born cells along the entire dorsoventral axis are required for these behaviors. We examined the role of distinct subpopulations of adult-born hippocampal granule cells in learning- and anxiety-related behaviors using low-dose focal x-irradiation directed specifically to the dorsal or ventral dentate gyrus. Our findings indicate a functional dissociation between a

SUBMITTER: Wu MV 

PROVIDER: S-EPMC4222246 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature