Towards the sequence-specific multivalent molecular recognition of cyclodextrin oligomers.

ABSTRACT: Sequence-specific multivalent molecular recognition has been recognized to play a major role in biological processes. Furthermore, sequence-specific recognition motifs have been used in various artificial systems in the last years, e.g., to emulate biological processes or to build up new materials with highly specific recognition domains. In this article, we present the preparation of cyclodextrin (CD)-based strands and complementary and non-complementary strands modified with guest molecules and the investigation of their complexation behavior towards each other by isothermal titration calorimetry (ITC). As complementary binding motifs n-butyl and α-CD and adamantane and β-CD were selected. It was found that it is possible to realize sequence-specific molecular recognition by the use of h

SUBMITTER: Kurlemann M 

PROVIDER: S-EPMC4222322 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature