Mouse hair cycle expression dynamics modeled as coupled mesenchymal and epithelial oscillators.

ABSTRACT: The hair cycle is a dynamic process where follicles repeatedly move through phases of growth, retraction, and relative quiescence. This process is an example of temporal and spatial biological complexity. Understanding of the hair cycle and its regulation would shed light on many other complex systems relevant to biological and medical research. Currently, a systematic characterization of gene expression and summarization within the context of a mathematical model is not yet available. Given the cyclic nature of the hair cycle, we felt it was important to consider a subset of genes with periodic expression. To this end, we combined several mathematical approaches with high-throughput, whole mouse skin, mRNA expression data to characterize aspects of the dynamics and the possible cell popul

SUBMITTER: Tasseff R 

PROVIDER: S-EPMC4222602 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature