Use of whole genome expression analysis in the toxicity screening of nanoparticles.

ABSTRACT: The use of nanoparticles (NPs) offers exciting new options in technical and medical applications provided they do not cause adverse cellular effects. Cellular effects of NPs depend on particle parameters and exposure conditions. In this study, whole genome expression arrays were employed to identify the influence of particle size, cytotoxicity, protein coating, and surface functionalization of polystyrene particles as model particles and for short carbon nanotubes (CNTs) as particles with potential interest in medical treatment. Another aim of the study was to find out whether screening by microarray would identify other or additional targets than commonly used cell-based assays for NP action. Whole genome expression analysis and assays for cell viability, interleukin secretion, oxidative

SUBMITTER: Frohlich E 

PROVIDER: S-EPMC4222661 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature