Progress in genetic association studies of plasma lipids.

ABSTRACT:

Purpose of review

This review summarizes recently published large-scale efforts elucidating the genetic architecture of lipid levels. A supplemental file with all genetic loci is provided for research purposes and we performed bioinformatic analyses of the genetic variants to give an oversight of involved pathways.

Recent findings

In total, 52 genes for HDL cholesterol, 42 genes for LDL cholesterol, 59 genes for total cholesterol, and 39 genes for triglycerides have been identified. Genetic overlap is present between the different traits and similar pathways are involved. Most of the SNPs that were detected in the European studies could be replicated in other ethnicities and these SNPs show the same direction of effect suggesting that the underlying genetic architecture of b

SUBMITTER: Asselbergs FW 

PROVIDER: S-EPMC4222789 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature