Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels.

ABSTRACT: Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing the effectiveness of conventional insecticides and threatening current vector control strategies, which has created an urgent need to identify new molecular targets against which novel classes of insecticides can be developed. We previously demonstrated that small molecule inhibitors of mammalian Kir channels represent promising chemicals for new mosquitocide development. In this study, high-throughput screening of approximately 30,000 chemically diverse small-molecules was employed to discover potent and selective inhibitors of Aedes aegypti Kir1 (AeKir1) channels h

SUBMITTER: Raphemot R 

PROVIDER: S-EPMC4222822 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature