A gatekeeper chaperone complex directs translocator secretion during type three secretion.

ABSTRACT: Many Gram-negative bacteria use Type Three Secretion Systems (T3SS) to deliver effector proteins into host cells. These protein delivery machines are composed of cytosolic components that recognize substrates and generate the force needed for translocation, the secretion conduit, formed by a needle complex and associated membrane spanning basal body, and translocators that form the pore in the target cell. A defined order of secretion in which needle component proteins are secreted first, followed by translocators, and finally effectors, is necessary for this system to be effective. While the secreted effectors vary significantly between organisms, the ∼20 individual protein components that form the T3SS are conserved in many pathogenic bacteria. One such conserved protein, referred to as

SUBMITTER: Archuleta TL 

PROVIDER: S-EPMC4222845 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature