Levetiracetam reduces abnormal network activations in temporal lobe epilepsy.

ABSTRACT:

Objective

We used functional MRI (fMRI) and a left-lateralizing verbal and a right-lateralizing visual-spatial working memory (WM) paradigm to investigate the effects of levetiracetam (LEV) on cognitive network activations in patients with drug-resistant temporal lobe epilepsy (TLE).

Methods

In a retrospective study, we compared task-related fMRI activations and deactivations in 53 patients with left and 54 patients with right TLE treated with (59) or without (48) LEV. In patients on LEV, activation patterns were correlated with the daily LEV dose.

Results

We isolated task- and syndrome-specific effects. Patients on LEV showed normalization of functional network deactivations in the right temporal lobe in right TLE during the right-lateralizing visual-spatial task and

SUBMITTER: Wandschneider B 

PROVIDER: S-EPMC4222853 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature