Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS.

ABSTRACT:

Objective

In the current exploratory study, we longitudinally measured immune parameters in the blood of individuals with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), and investigated their relationship to disease duration and clinical and radiologic measures of CNS injury.

Methods

Peripheral blood mononuclear cells (PBMCs) and plasma were obtained from subjects with RRMS, SPMS, and from healthy controls on a monthly basis over the course of 1 year. MRI and Expanded Disability Status Scale evaluations were performed serially. PBMCs were analyzed by enzyme-linked immunosorbent spot assay to enumerate myelin basic protein-specific interleukin (IL)-17- and interferon (IFN)-γ-producing cells. Plasma concentrations of proinfla

SUBMITTER: Huber AK 

PROVIDER: S-EPMC4222856 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature