Diuretic exposure in premature infants from 1997 to 2011.

ABSTRACT:

Objective

Diuretics are often prescribed off-label to premature infants, particularly to prevent or treat bronchopulmonary dysplasia. We examined their use and safety in this group.

Study design

Retrospective cohort study of infants < 32 weeks gestation and < 1,500 g birth weight exposed to diuretics in 333 neonatal intensive care units from 1997 to 2011. We examined use of acetazolamide, amiloride, bumetanide, chlorothiazide, diazoxide, ethacrynic acid, furosemide, hydrochlorothiazide, mannitol, metolazone, or spironolactone combination. Respiratory support and fraction of inspired oxygen on the first day of each course of diuretic use were identified.

Results

About 37% (39,357/107,542) infants were exposed to at least one diuretic; furosemide was the most commonly u

SUBMITTER: Laughon MM 

PROVIDER: S-EPMC4223004 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature