Restoring mood balance in depression: ketamine reverses deficit in dopamine-dependent synaptic plasticity.

ABSTRACT:

Background

One of the most novel and exciting findings in major depressive disorder research over the last decade is the discovery of the fast-acting and long-lasting antidepressant effects of ketamine. Indeed, the therapeutic effects of classic antidepressants, such as selective serotonin reuptake inhibitors, require a month or longer to be expressed, with about a third of major depressive disorder patients resistant to treatment. Clinical studies have shown that a low dose of ketamine exhibits fast-acting relatively sustained antidepressant action, even in treatment-resistant patients. However, the mechanisms of ketamine action at a systems level remain unclear.

Methods

Wistar-Kyoto rats were exposed to inescapable, uncontrollable footshocks. To evaluate learned helplessne

SUBMITTER: Belujon P 

PROVIDER: S-EPMC4223010 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature