Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression.

ABSTRACT:

Purpose

To investigate the characteristics of nuclear Overhauser enhancement (NOE) imaging signals in the brain at 7T.

Methods

Fresh hen eggs, as well as six healthy, and six C6 glioma-bearing Wistar rats were scanned using chemical exchange saturation transfer-magnetic resonance imaging (CEST-MRI) and chemical exchange saturation transfer-magnetic resonance spectroscopy (CEST-MRS) sequences (saturation duration 3 s, power 1.47 µT) with and without lipid suppression. CEST data were acquired over an offset range of -6 to +6 ppm relative to the water resonance in 0.5 ppm steps.

Results

The water signals were not disrupted by other protons during the CEST-MRS sequences, and true NOE signals could be observed. Using the CEST-MRI sequence without lipid suppression, pseudo

SUBMITTER: Lu J 

PROVIDER: S-EPMC4223020 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature