Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging.

ABSTRACT:

Objective

To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone.

Methods

We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We investigated 2 groups of cognitively normal participants: one group with evidence of preclinical AD as assessed by CSF markers of AD and the other group with normal CSF biomarkers.

Results

There were significant interactions between age and biomarker status in the default-mode, dorsal attention, and salience resting-state networks. In the group with evidence of preclinical AD, there were dramatic changes in functional connectivity with age. In the group w

SUBMITTER: Brier MR 

PROVIDER: S-EPMC4223085 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature