Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study.

ABSTRACT:

Objective

The objective of this study was to assess the level of agreement between stroke subtype classifications made using the Trial of Org 10172 Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems.

Methods

Study subjects included 13,596 adult men and women accrued from 20 US and European genetic research centers participating in the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN). All cases had independently classified TOAST and CCS stroke subtypes. Kappa statistics were calculated for the 5 major ischemic stroke subtypes common to both systems.

Results

The overall agreement between TOAST and CCS was moderate (agreement rate, 70%; κ = 0.59, 95% confidence interval [CI] 0.58-0.60). Agreem

SUBMITTER: McArdle PF 

PROVIDER: S-EPMC4223086 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature