Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection.

ABSTRACT:

Objective

We examined the longitudinal effects of primary HIV infection (PHI) and responses to early antiretroviral therapy (ART) on the brain using high-field magnetic resonance spectroscopy (MRS).

Methods

Cerebral metabolites were measured longitudinally with 4T proton MRS and assessed for ART effects in participants with PHI. Levels of glutamate (Glu), N-acetylaspartate (NAA), myo-inositol (MI), and choline-containing metabolites (Cho) were measured relative to creatine + phosphocreatine (Cr) in anterior cingulate, basal ganglia, frontal white matter, and parietal gray matter.

Results

Fifty-three participants recruited at median 3.7 months post HIV transmission were followed a median 6.0 months. A total of 23 participants initiated ART during follow-up. Prior to AR

SUBMITTER: Young AC 

PROVIDER: S-EPMC4223087 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature