Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient.

ABSTRACT:

Background

Mycobacterium tuberculosis is characterized by a low mutation rate and a lack of genetic recombination. Yet, the rise of extensively resistant strains paints a picture of a microbe with an impressive adaptive potential. Here we describe the first documented case of extensively drug-resistant tuberculosis evolved from a susceptible ancestor within a single patient.

Results

Genome sequences of nine serial M. tuberculosis isolates from the same patient uncovered a dramatic turnover of competing lineages driven by the emergence, and subsequent fixation or loss of single nucleotide polymorphisms. For most drugs, resistance arose through independent emergence of mutations in more than one clone, of which only one ultimately prevailed as the clone carrying it expanded, d

SUBMITTER: Eldholm V 

PROVIDER: S-EPMC4223161 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature