Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum.

ABSTRACT:

Background

Proteins belonging to the serine protease inhibitor (serpin) superfamily play essential physiological roles in many organisms. In pathogens, serpins are thought to have evolved specifically to limit host immune responses by interfering with the host immune-stimulatory signals. Serpins are less well characterised in parasitic helminths, although some are thought to be involved in mechanisms associated with host immune modulation. In this study, we cloned and partially characterised a secretory serpin from Schistosoma japonicum termed SjB6, these findings provide the basis for possible functional roles.

Methods

SjB6 gene was identified through database mining of our previously published microarray data, cloned and detailed sequence and structural analysis and compar

SUBMITTER: Molehin AJ 

PROVIDER: S-EPMC4223420 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature